Department of Ophthalmology, Ehime University School of Medicine, Shitsukawa, Toon-City, Ehime, Japan.
J Ocul Pharmacol Ther. 2009 Dec;25(6):563-5. doi: 10.1089/jop.2009.0069.
To report a case of fungal keratitis caused by Colletotrichum gloeosporioides, which is a rare pathogen in humans.
An 80-year-old woman developed fungal keratitis after having sustained a traumatic injury during field work. The patient was initially examined by slit-lamp biomicroscopy and the Heidelberg Retina Tomograph II-Rostock Cornea Module (HRT II-RCM). Corneal scrapings were collected and submitted for laboratory investigations.
Many septate, hyphae-like interlocking and branching white lines were observed in the area of the infiltrate by HRT II-RCM. A tentative diagnosis of fungal keratitis was made, and the patient was treated with systemic and topical voriconazole and pimaricin ophthalmic ointment. The infectious focus resolved within 2 weeks, and there were no signs of a recurrence after 3 months of treatment with the antifungal agents. The culture of the corneal scraping grew C. gloeosporioides.
HRT II-RCM was useful in detecting filamentous fungi in the cornea. The treatment with voriconazole and pimaricin was effective in the treatment of C. gloeosporioides keratitis.
报告一例由胶孢炭疽菌引起的真菌性角膜炎，胶孢炭疽菌是人眼罕见的病原体。
一名 80 岁女性在田间劳作时受外伤后发生真菌性角膜炎。患者最初通过裂隙灯生物显微镜和海德堡视网膜断层扫描仪 II-罗托卡角膜模块（HRT II-RCM）进行检查。采集角膜刮片进行实验室检查。
HRT II-RCM 观察到浸润区有许多分隔、菌丝样交错和分支的白线。疑似真菌性角膜炎，给予全身和局部伏立康唑和制霉菌素眼膏治疗。感染病灶在 2 周内消退，抗真菌治疗 3 个月后无复发迹象。角膜刮片培养出胶孢炭疽菌。
HRT II-RCM 可用于检测角膜中的丝状真菌。伏立康唑和制霉菌素治疗胶孢炭疽菌角膜炎有效。
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