National centre for cell science, S.P. Pune university campus, 411004 Pune, India.
Department of microbiology, Bharati Vidyapeeth Deemed university medical college, 411043 Pune, India.
J Mycol Med. 2017 Sep;27(3):407-411. doi: 10.1016/j.mycmed.2017.04.009. Epub 2017 May 10.
Colletotrichum species have been reported infrequently as the cause of keratitis or subcutaneous lesions. The patient we describe developed keratitis after ocular trauma. The sample from the corneal scrapings grew Colletotrichum gloeosporioides as identified from morphological characters and DNA sequence of the 'Internal Transcribed Spacer' (ITS) region. The patient underwent topical application of amphotericin-B followed by itraconazole and natamycin treatment. Simultaneous oral voriconazole regimen leads to complete regression of corneal ulcer. This report highlights the fact that early and accurate identification and therapy can resolve keratitis caused by rare pathogen C. gloeosporioides.
炭疽菌属种曾有报道为角膜炎或皮下病变的致病原因。我们描述的这位患者在眼部外伤后发生了角膜炎。从角膜刮片样本中分离出的炭疽菌，通过形态学特征和‘内部转录间隔区’（ITS）区域的 DNA 序列鉴定为胶孢炭疽菌。患者接受了局部应用两性霉素 B 治疗，随后使用伊曲康唑和那他霉素。同时给予口服伏立康唑方案治疗，导致角膜溃疡完全消退。本报告强调了早期准确鉴定和治疗可以解决由罕见病原体胶孢炭疽菌引起的角膜炎这一事实。
