Academic Unit of Respiratory Medicine, Royal Free Campus, UCL Medical School, London NW3 2PF, UK.
Thorax. 2010 Jan;65(1):85-90. doi: 10.1136/thx.2008.112888.
This review presents the evidence that chronic obstructive pulmonary disease (COPD) is associated with significant sinonasal symptoms, inflammation and airway obstruction. Upper airway symptoms in COPD cause impairment to quality of life. The severity of upper airway involvement relates to that present in the lower airway, suggesting that the nose may be used to model the lung in COPD. More importantly, relationships between upper and lower airway bacteria and inflammation, and the association between sinusitis and treatment failure at exacerbation raise the possibility that nasal intervention in COPD may not only improve health status but may also affect important clinical outcomes such as exacerbation frequency.
这篇综述介绍了证据表明慢性阻塞性肺疾病（COPD）与显著的鼻-鼻窦症状、炎症和气道阻塞有关。COPD 的上呼吸道症状导致生活质量受损。上呼吸道受累的严重程度与下呼吸道相似，这表明鼻腔可能用于 COPD 中的肺部模型。更重要的是，上、下呼吸道细菌和炎症之间的关系，以及鼻窦炎与加重期治疗失败之间的关联，提出了这样一种可能性，即在 COPD 中进行鼻腔干预不仅可以改善健康状况，还可能影响重要的临床结局，如加重频率。
