Department of Medicine, Division of Rheumatology, Brigham and Women's Hospital, Boston, Massachusetts 02115, USA.
Nat Rev Immunol. 2010 Jan;10(1):24-35. doi: 10.1038/nri2685.
Transcriptional control mechanisms chart the course of the inflammatory response by synthesizing mRNAs encoding proteins that promote or inhibit inflammation. Because these mRNAs can be long-lived, turning off their synthesis does not rapidly stop or change the direction of inflammation. Post-transcriptional mechanisms that modify mRNA stability and/or translation provide more rapid and flexible control of this process and are particularly important in coordinating the initiation and resolution of inflammation. Here, I review the surprising variety of post-transcriptional control mechanisms that regulate the initiation and resolution of inflammation and discuss how these mechanisms are integrated to coordinate this essential process.
转录控制机制通过合成编码促进或抑制炎症的蛋白质的 mRNA 来规划炎症反应的进程。由于这些 mRNA 可以具有较长的寿命，因此关闭它们的合成并不能迅速停止或改变炎症的方向。可以改变 mRNA 稳定性和/或翻译的转录后机制为该过程提供了更快速和灵活的控制，并且在协调炎症的起始和消退中特别重要。在这里，我回顾了调节炎症起始和消退的令人惊讶的多种转录后控制机制，并讨论了这些机制如何整合以协调这一基本过程。
