Department of Psychology and Behavioral Science, Zhejiang University, Hangzhou, China.
Int J Geriatr Psychiatry. 2010 Nov;25(11):1127-33. doi: 10.1002/gps.2442.
The aim of this study was to examine the reliability and validation of the 9-item Patient Health Questionnaire (PHQ-9) for late-life depression in Chinese primary care.
In the primary care clinics (PCCs) of Hangzhou city, we recruited 364 older patients (aged ≥ 60) for the PHQ-9 screening. Then 77 of them were further interviewed with Structured Clinical Interview for DSM Disorders (SCID) for the diagnosis of major depression in late life. Statistic strategies for the feasibility, reliability, validity, and receiver operating characteristic curve were performed.
The mean administration time was 7.5 min, and the Cronbach's α was 0.91. The optimal cut-off score of PHQ-9 ≥ 9 revealed a sensitivity of 0.86, specificity of 0.77, and positive likelihood ratio of 5.73. The area under the curve (AUC) in this study was 0.92 (SD = 0.02, 95% CI 0.88-0.96). The PHQ-2 also revealed good sensitivity (0.84) and specificity (0.90) at the cut-off point ≥ 3.
The PHQ-9 performs well and has acceptable psychometric properties for screening of patients with late-life depression in Chinese primary care settings.
本研究旨在检验中文版 9 项患者健康问卷（PHQ-9）用于中国基层医疗中老年人群迟发性抑郁症的信度和效度。
在杭州市的基层医疗诊所（PCC），我们对 364 名年龄≥60 岁的老年患者进行 PHQ-9 筛查。然后，其中 77 名患者进一步接受 DSM 障碍定式临床访谈（SCID）访谈，以诊断晚年的重度抑郁症。采用统计策略进行可行性、信度、效度和受试者工作特征曲线分析。
平均管理时间为 7.5 分钟，Cronbach's α 为 0.91。PHQ-9≥9 的最佳截断分数显示出 0.86 的敏感性、0.77 的特异性和 5.73 的阳性似然比。本研究中的曲线下面积（AUC）为 0.92（SD=0.02，95%CI 0.88-0.96）。PHQ-2 在截断点≥3 时也显示出良好的敏感性（0.84）和特异性（0.90）。
PHQ-9 在中国基层医疗环境中用于筛查中老年人群迟发性抑郁症具有良好的性能和可接受的心理测量学特性。
