Urman B, Pride S M, Yuen B H
Department of Obstetrics and Gynecology, Faculty of Medicine, University of British Columbia, Vancouver, Canada.
Obstet Gynecol. 1991 Apr;77(4):595-8.
Nine postmenopausal women with symptoms and signs of androgen excess due to long-term use of an injectable androgen-estrogen combination were studied retrospectively. Cosmetically disturbing hirsutism was the major complaint in eight subjects. Other symptoms included hot flushes, decreased libido, mood changes, depression, and postmenopausal bleeding in the one patient with an intact uterus. Seven women had clitorimegaly; the clitoral index ranged from 45-120 mm2 (normal up to 35). Serum total testosterone levels were elevated in eight women, ranging from 5.7-14.9 nmol/L (normal up to 2.43). The androgen-estrogen combination was discontinued and oral or transdermal estrogen replacement was instituted. In five women followed serially for 16-24 months, elevated testosterone levels required 12-20 months to return to the normal premenopausal range.
对9名因长期使用注射用雄激素 - 雌激素组合而出现雄激素过多症状和体征的绝经后女性进行了回顾性研究。8名受试者的主要诉求是美容方面令人困扰的多毛症。其他症状包括潮热、性欲减退、情绪变化、抑郁，以及1名子宫完整的患者出现绝经后出血。7名女性有阴蒂增大；阴蒂指数范围为45 - 120平方毫米（正常上限为35）。8名女性血清总睾酮水平升高，范围为5.7 - 14.9纳摩尔/升（正常上限为2.43）。停用雄激素 - 雌激素组合，并开始口服或经皮雌激素替代治疗。对5名女性进行了连续16 - 24个月的随访，睾酮水平升高需要12 - 20个月才能恢复到绝经前正常范围。
