Inoue T, Inoue T, Ikeda H, Teshima T, Yamazaki H, Murayama S, Othani M, Ozeki S
Department of Radiation Oncology, Osaka University Medical School, Japan.
Strahlenther Onkol. 1993 Oct;169(10):584-9.
There were a few reports to compare the treatment results of glottic and supraglottic carcinoma. We investigated the difference of glottic and supraglottic carcinoma. From 1967 through 1985, 338 cases with early glottic (T1: 210, T2: 52) and supraglottic carcinoma (T1: 34, T2: 42) were treated with the conventional fractionation of radiation and evaluated the tumor response during radiation at the Department of Radiology, Osaka University Hospital. The ten-year actuarial survival rates of T1, T2 glottic and T1 and T2 supraglottic carcinoma were 63%, 64%, 58% and 46%, the corresponding ten-year cause-specific survival rates 92%, 89%, 88% and 78%, and the corresponding ten-year local control rates 76%, 67%, 69% and 59%, respectively. Tumor clearance rates of T1 and T2 glottic and T1 and T2 supraglottic carcinoma at 40 Gy were 68%, 40%, 35% and 24%, respectively. The local control rate of the tumor which disappeared at 40 Gy was 84%, that persisted at 40 Gy and disappeared at 60 Gy 69%, and that persisted at 60 Gy 33%. The local control rate and the tumor clearance rate of T1 glottic carcinoma were the highest among early laryngeal carcinoma, and those of T2 glottic carcinoma were the same as those of T1 supraglottic cases. The local control rate, the cause-specific survival rate, and the actuarial survival rate of T2 supraglottic were significantly lower than other cases.
有一些报告比较了声门癌和声门上癌的治疗结果。我们研究了声门癌和声门上癌的差异。1967年至1985年期间，大阪大学医院放射科对338例早期声门癌（T1：210例，T2：52例）和声门上癌（T1：34例，T2：42例）采用传统分割放疗，并评估放疗期间的肿瘤反应。T1、T2声门癌以及T1和T2声门上癌的十年精算生存率分别为63%、64%、58%和46%，相应的十年病因特异性生存率分别为92%、89%、88%和78%，相应的十年局部控制率分别为76%、67%、69%和59%。T1和T2声门癌以及T1和T2声门上癌在40 Gy时的肿瘤清除率分别为68%、40%、35%和24%。在40 Gy时消失的肿瘤的局部控制率为84%，在40 Gy时持续存在并在60 Gy时消失的肿瘤的局部控制率为69%，在60 Gy时持续存在的肿瘤的局部控制率为33%。早期喉癌中，T1声门癌的局部控制率和肿瘤清除率最高，T2声门癌的局部控制率与T1声门上癌的相同。T2声门上癌的局部控制率、病因特异性生存率和精算生存率显著低于其他病例。
