Inoue T, Inoue T, Ikeda H, Teshima T, Murayama S
Department of Radiology, Osaka Teishin Hospital, Japan.
Strahlenther Onkol. 1992 Oct;168(10):579-83.
From 1967 through 1985, 358 cases of early glottic carcinoma were treated with telecobalt therapy at the Department of Radiology, Osaka University Medical School. Among 278 cases treated with 2 Gy a day, the tumor response of 262 cases at 40, 50 and 60 Gy were evaluated by direct or indirect laryngoscope. The five-year local control rates of these evaluable cases of T1 and T2 glottic carcinoma were 79% and 70%, respectively. The local control rates of T1 glottic carcinoma with tumor clearance and persistence at 40 Gy were 83% (119/143) and 64% (43/67), and those of T2 cases were 86% (18/21) and 58% (18/31), respectively. The local control rates of the cases with tumor clearance and persistence at 40 Gy were same between T1 and T2 cases. The tumor clearance rates of T1 cases were significantly higher than those of T2 cases (p < 0.005). T2 glottic carcinoma had larger tumor volumes and slower tumor regression and resulted in lower control rates compared with T1 glottic carcinoma. The difference in the radiation dose of T1 and T2 glottic carcinoma with the same clearance rate was estimated as 15 Gy using logit analysis.
1967年至1985年期间，大阪大学医学院放射科采用远距离钴治疗法治疗了358例早期声门癌。在每天接受2 Gy治疗的278例患者中，通过直接或间接喉镜对262例患者在40、50和60 Gy时的肿瘤反应进行了评估。这些可评估的T1和T2声门癌病例的五年局部控制率分别为79%和70%。40 Gy时肿瘤清除和持续存在的T1声门癌局部控制率分别为83%（119/143）和64%（43/67），T2病例的局部控制率分别为86%（18/21）和58%（18/31）。40 Gy时肿瘤清除和持续存在的病例中，T1和T2病例的局部控制率相同。T1病例的肿瘤清除率显著高于T2病例（p < 0.005）。与T1声门癌相比，T2声门癌肿瘤体积更大，肿瘤消退更慢，导致控制率更低。使用logit分析估计，具有相同清除率的T1和T2声门癌的放射剂量差异为15 Gy。
