Lee H K, Chai C Y, Chung P M, Chen C C
Brain Res Bull. 1977 Sep-Oct;2(5):375-80. doi: 10.1016/0361-9230(77)90071-5.
Single unit activity was recorded with glass microelectrodes in the reticular formation of the medulla oblongata of cats lightly anesthetized with urethan, while medullary temperature was changed by surface irrigation with warm or cold artificial cerebrospinal fluid. In addition, water-perfusion thermodes were implanted over the preoptic anterior hypothalamus (POAH) region, and the effects of heating and cooling of the POAH on firing rate of medullary units were studied. One hundred and twenty-five temperature-sensitive neurons were studied in the medullary reticular formation. Out of these 125 neurons, 80 were warm-sensitive and 45 were cold-sensitive. Sixteen warm-sensitive medullary neurons were examined in responses to changes of POAH temperature. Ten units (62.5%) responded, and the remaining 6 units were not responsive to changes of the POAH temperature. Of 13 cold-sensitive neurons examined, 10 units (77.0%) responded. On the other hand, only 1 out of 7 (14.3%) temperature-insensitive neurons tested did respond to changes in the POAH temperature. These results suggest that the temperature signals sent out from thermosensitive structures in the hypothalamus might be transmitted to a major portion of temperature-sensitive neurons in the medullary reticular formation.
用玻璃微电极在以氨基甲酸乙酯轻度麻醉的猫的延髓网状结构中记录单个单位活动，同时通过用温热或冷的人工脑脊液进行表面灌注来改变延髓温度。此外，将水灌注式热敏电阻植入视前区下丘脑前部（POAH）区域，研究POAH加热和冷却对延髓单位放电率的影响。在延髓网状结构中研究了125个温度敏感神经元。在这125个神经元中，80个是热敏的，45个是冷敏的。检查了16个热敏延髓神经元对POAH温度变化的反应。10个单位（62.5%）有反应，其余6个单位对POAH温度变化无反应。在检查的13个冷敏神经元中，10个单位（77.0%）有反应。另一方面，在测试的7个温度不敏感神经元中，只有1个（14.3%）对POAH温度变化有反应。这些结果表明，下丘脑热敏结构发出的温度信号可能会传递到延髓网状结构中大部分温度敏感神经元。
