用 5-羟色氨酸治疗绝经期热潮红。
Treatment of menopausal hot flashes with 5-hydroxytryptophan.
机构信息
Departments of Psychiatry and Behavioral Neurosciences and Obstetrics and Gynecology, Wayne State University School of Medicine, C.S. Mott Center for Human Growth and Development, 275 E. Hancock, Detroit, MI 48201, USA.
出版信息
Maturitas. 2010 Apr;65(4):383-5. doi: 10.1016/j.maturitas.2009.11.025. Epub 2009 Dec 23.
OBJECTIVE
Much recent research has focused on nonhormonal treatments for menopausal hot flashes. The purpose of the present study was to determine the effects of 5-hydroxytroptophan (5-HTP), the immediate precursor of serotonin, upon menopausal hot flashes. Selective, serotonergic, reuptake inhibitors (SSRIs), which increase the amount of serotonin in the synaptic gap, have shown some promise in the amelioration of hot flashes.
METHODS
We administered 5-HTP or placebo, in double-blind fashion, to 24 postmenopausal women reporting frequent hot flashes. Treatment outcome was measured using a miniature, electronic, hot flash recorder.
RESULTS
No significant effects of 150 mg/day 5-HTP upon hot flash frequency were found. The 5-HTP group had 23.8 + or - 5.7 (SD) hot flashes/24 h prior to treatment and 18.5 + or - 9.6 at the end of treatment. The placebo group had 18.5 + or - 9.6 before treatment and 22.6 + or - 12.4 at treatment completion.
CONCLUSIONS
At the dose given, 5-HTP does not significantly ameliorate frequency of menopausal hot flashes, as measured objectively with an electronic recorder. Given the small size, this study must be considered preliminary in nature.
目的
近期大量研究集中于绝经后热潮红的非激素治疗。本研究旨在确定 5-羟色氨酸（5-HTP），即血清素的直接前体，对绝经后热潮红的影响。选择性血清素再摄取抑制剂（SSRIs），可增加突触间隙的血清素含量，在改善热潮红方面显示出一定的前景。
方法
我们以双盲方式向 24 名报告频繁热潮红的绝经后妇女给予 5-HTP 或安慰剂。使用微型电子热潮红记录仪测量治疗效果。
结果
每天 150 毫克 5-HTP 对热潮红频率没有明显影响。5-HTP 组治疗前热潮红次数为 23.8+/-5.7（SD）/24 小时，治疗结束时为 18.5+/-9.6。安慰剂组治疗前为 18.5+/-9.6，治疗结束时为 22.6+/-12.4。
结论
在给予的剂量下，5-HTP 并不能显著改善绝经后热潮红的频率，这是通过电子记录仪客观测量的。考虑到研究规模较小，本研究必须被认为是初步的。
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