Division of Respiratory Medicine, Dept of Paediatrics, Radboud University Medical Centre, Nijmegen Medical Centre, Nijmegen, The Netherlands.
Eur Respir J. 2010 Jul;36(1):157-63. doi: 10.1183/09031936.00125009. Epub 2009 Dec 23.
Measuring interrupter resistance (R(int)) is an increasingly popular lung function technique and especially suitable for preschool children because it is simple, quick and requires only passive cooperation. A European Respiratory Society (ERS)/American Thoracic Society (ATS) Task Force recently published empirical recommendations related to procedures, limitations and interpretation of the technique. However, for valid interpretation, high-quality reference equations are required and these have been lacking. The aim of the present study was to collate R(int) data from healthy children in order to produce more robust reference equations. A further aim was to examine the influence of methodological differences on predicted R(int) values. R(int) data from healthy children were collected from published and unpublished sources. Reference equations for expiratory and inspiratory R(int) were developed using the LMS (lambda, mu, sigma) method. Data from 1,090 children (51% males) aged 3-13 yrs were collated to construct sex-specific reference equations for expiratory R(int) and data from 629 children (51% males) were collated for inspiratory R(int). Height was the best independent predictor of both expiratory and inspiratory R(int). Differences between centres were clinically irrelevant, and differences between ethnic groups could not be examined. The availability of a large and generalisable sample and the use of modern statistical techniques enabled the development of more appropriate reference equations for R(int) in young children.
测量阻断法呼吸阻力（R(int)）是一种日益流行的肺功能检测技术，尤其适用于学龄前儿童，因为它简单、快速，只需要被动配合。一个欧洲呼吸学会（ERS）/美国胸科学会（ATS）工作组最近发布了与该技术的程序、局限性和解释相关的经验建议。然而，为了进行有效的解释，需要高质量的参考方程，而这些方程一直缺乏。本研究的目的是汇集健康儿童的 R(int)数据，以生成更稳健的参考方程。另一个目的是研究方法差异对预测 R(int)值的影响。从已发表和未发表的来源收集了健康儿童的 R(int)数据。使用 LMS（lambda、mu、sigma）方法开发了呼气和吸气 R(int)的参考方程。共汇集了 1,090 名（51%为男性）年龄在 3-13 岁的儿童的数据，以构建适合男性和女性的呼气 R(int)参考方程；汇集了 629 名（51%为男性）儿童的数据，以构建吸气 R(int)参考方程。身高是预测呼气和吸气 R(int)的最佳独立预测因子。中心之间的差异在临床上无意义，不同种族之间的差异无法进行检验。由于获得了大量的、具有代表性的样本，并采用了现代统计学技术，因此能够为幼儿的 R(int)开发出更合适的参考方程。
