Hopkins Lupus Center, Division of Rheumatology, Department of Internal Medicine, Johns Hopkins University, Baltimore, Maryland 21205, USA.
J Rheumatol. 2010 Feb;37(2):341-5. doi: 10.3899/jrheum.090829. Epub 2009 Dec 23.
Pancreatitis is a rare but potentially life-threatening complication of systemic lupus erythematosus (SLE). Vasculitis of the gastrointestinal tract is the most commonly proposed mechanism. We determined the frequency of SLE-related pancreatitis in the Hopkins Lupus Cohort.
A large prospective cohort of 1811 patients with SLE was reviewed and clinical and laboratory measures of SLE patients who developed pancreatitis were compared to patients who did not develop pancreatitis.
Four percent of patients with SLE had pancreatitis due to SLE. The best multivariate model of clinical and laboratory associations included hypertriglyceridemia, psychosis, pleurisy, gastritis, and anemia.
Hypertriglyceridemia appears to be a strong associate of pancreatitis in SLE, but antiphospholipid antibodies are not. SLE patients with psychosis and pleurisy are at increased risk for pancreatitis.
胰腺炎是系统性红斑狼疮（SLE）罕见但潜在致命的并发症。胃肠道血管炎是最常被提出的发病机制。我们确定了霍普金斯狼疮队列中与 SLE 相关的胰腺炎的频率。
对 1811 例 SLE 患者进行了大型前瞻性队列研究，并比较了发生胰腺炎和未发生胰腺炎的 SLE 患者的临床和实验室检查结果。
4%的 SLE 患者因 SLE 而发生胰腺炎。包括高脂血症、精神病、胸膜炎、胃炎和贫血在内的最佳多变量模型可以更好地对临床和实验室相关性进行预测。
高脂血症似乎是 SLE 患者胰腺炎的一个强烈关联因素，但抗磷脂抗体并非如此。有精神病和胸膜炎的 SLE 患者发生胰腺炎的风险增加。
