Petri M, Genovese M
Department of Medicine, Johns Hopkins University School of Medicine, Baltimore, MD.
J Rheumatol. 1992 Oct;19(10):1559-65.
To determine the incidence of and risk factors for hospitalization in systemic lupus erythematosus (SLE).
A prospective study of hospitalizations in 1989 and 1990 in the Hopkins Lupus Cohort was conducted.
Of 261 patients with SLE in the Hopkins Cohort, 147 (56.3%) were hospitalized in 1989 or 1990. The incidence of hospitalization was 0.69 admissions/person-year. The mean length of stay was 9.6 days +/- 12.7 (SD). Activity of SLE accounted for 35% of admissions. Risk factors for hospitalization for active lupus in 1990 included activity of SLE in 1989 (measured by either the highest physician's global assessment in 1989, p = 0.004, highest lupus activity index (LAI) score in 1989, p = 0.002, or highest systemic lupus erythematosus disease activity index score in 1989, p = 0.008), an average prednisone dose greater than 10 mg in 1989 (p = 0.002), and the presence of neurologic lupus in 1989 (p = 0.02). Medical admissions other than for active SLE accounted for an additional 27% of admissions; one-half of these admissions (47%) were for complications of SLE and/or its treatment, with coronary artery disease the most common (21% of medical admissions). Infections were responsible for 14% of admissions. The majority of infections were bacterial (90%). Risk factors for hospitalization for infection in 1990 included active SLE in 1989 (p = 0.03), average prednisone dose of greater than 10 mg in 1989 (p = 0.04), immunosuppressive drug use in 1989 (p = 0.003), neurologic SLE in 1989 (p = 0.02) and previous hospitalization in 1989 (p = 0.03).
Hospitalization is common in the Hopkins Lupus Cohort, with active SLE (35%), infection (14%, infection and/or active SLE; 11%, infection alone) and medical complications of SLE (13%) as the 3 most common causes.
确定系统性红斑狼疮（SLE）患者住院的发生率及危险因素。
对霍普金斯狼疮队列1989年和1990年的住院情况进行前瞻性研究。
在霍普金斯队列的261例SLE患者中，147例（56.3%）在1989年或1990年住院。住院发生率为0.69次入院/人年。平均住院时间为9.6天±12.7（标准差）。SLE活动导致35%的入院。1990年活动性狼疮住院的危险因素包括1989年的SLE活动（通过1989年最高的医生整体评估衡量，p = 0.004；1989年最高的狼疮活动指数（LAI）评分，p = 0.002；或1989年最高的系统性红斑狼疮疾病活动指数评分，p = 0.008）、1989年平均泼尼松剂量大于10 mg（p = 0.002）以及1989年存在神经精神性狼疮（p = 0.02）。除活动性SLE外的内科入院占另外27%的入院；其中一半（47%）是SLE及其治疗的并发症，冠状动脉疾病最为常见（占内科入院的21%）。感染占入院的14%。大多数感染为细菌性（90%）。1990年感染住院的危险因素包括1989年的活动性SLE（p = 0.03）、1989年平均泼尼松剂量大于10 mg（p = 0.04）、1989年使用免疫抑制药物（p = 0.003）、1989年的神经精神性狼疮（p = 0.02）以及1989年曾住院（p = 0.03）。
在霍普金斯狼疮队列中住院很常见，活动性SLE（35%）、感染（14%，感染和/或活动性SLE；11%，单纯感染）和SLE的内科并发症（13%）是最常见的3个原因。
