Department of Radiology, Duke University Medical Center, Duke North-Room 1417, Erwin Rd, Durham, NC 27710, USA.
Radiology. 2010 Jan;254(1):179-87. doi: 10.1148/radiol.09090486.
To retrospectively compare a two-dimensional (2D) and a three-dimensional (3D) technique for in-phase (IP) and opposed-phase (OP) single-breath-hold 3-T magnetic resonance (MR) imaging in the characterization of adrenal lesions, with histopathologic confirmation, computed tomographic findings, or imaging follow-up for a minimum of 6 months used as the reference standard.
This retrospective HIPAA-compliant study was approved by institutional review board, and a waiver of informed consent was obtained. Thirty-four patients (mean age, 57 years) with 37 adrenal lesions underwent 3-T adrenal MR imaging with both 2D and 3D single-breath-hold dual gradient-echo (GRE) MR sequences. Signal intensity (SI) index and adrenal-to-spleen, adrenal-to-liver, and adrenal-to-muscle SI ratios for each lesion were compared between the two techniques by using repeated-measures analysis of variance. The area under the receiver operating characteristic curve (AUC) for each evaluation method was determined, with retrospective selection of suggested thresholds.
For the 2D and 3D techniques, the mean SI index and SI ratios were significantly different between adenomas and nonadenomas (P < .05), except for the adrenal-to-liver SI ratio with the 2D technique and the adrenal-to-muscle SI ratio with both techniques. For all evaluation methods, the AUCs were higher, although not statistically significant, for the 3D technique. The two techniques exploited different suggested thresholds for discriminating adenomas from nonadenomas.
Adrenal adenomas can be readily differentiated from nonadenomas at 3-T MR imaging with either a 2D or 3D single-breath-hold dual GRE MR technique. Depending on the acquisition technique, different suggested thresholds need to be selected for various evaluation methods.
回顾性比较二维（2D）和三维（3D）同相位（IP）和反相位（OP）单次屏气 3T 磁共振（MR）成像技术在肾上腺病变特征分析中的作用，以组织病理学、计算机断层扫描（CT）发现或至少 6 个月的影像学随访为参考标准。
本回顾性 HIPAA 合规性研究经机构审查委员会批准，并获得了知情同意豁免。34 例（平均年龄，57 岁）患者的 37 个肾上腺病变均行 3T 肾上腺 MR 成像，包括 2D 和 3D 单次屏气双梯度回波（GRE）MR 序列。采用重复测量方差分析比较两种技术的每个病变的信号强度（SI）指数和肾上腺与脾脏、肾上腺与肝脏、肾上腺与肌肉的 SI 比值。确定每个评估方法的受试者工作特征曲线（ROC）下面积（AUC），并进行回顾性选择建议阈值。
对于 2D 和 3D 技术，除了 2D 技术的肾上腺与肝脏 SI 比值和两种技术的肾上腺与肌肉 SI 比值外，腺瘤与非腺瘤之间的平均 SI 指数和 SI 比值差异均有统计学意义（P＜.05）。对于所有评估方法，3D 技术的 AUC 虽然略高，但差异无统计学意义。两种技术在区分腺瘤和非腺瘤时利用了不同的建议阈值。
在 3T MR 成像中，无论是 2D 还是 3D 单次屏气双 GRE MR 技术，肾上腺腺瘤都可以很容易地与非腺瘤区分开来。根据采集技术，各种评估方法需要选择不同的建议阈值。
