University of California, San Diego, Skaggs School of Pharmacy and Pharmaceutical Sciences, 9500 Gilman Drive, MC 0714, La Jolla, CA 92093-0714, USA.
J Clin Microbiol. 2010 Feb;48(2):623-5. doi: 10.1128/JCM.02397-09. Epub 2009 Dec 23.
Carbapenems (CARBs) are the primary treatment for infections caused by extended-spectrum beta-lactamase (ESBL)-producing Klebsiella pneumoniae strains. Production of a serine carbapenemase, KPC, is increasing alarmingly in the United States and is probably contributing to CARB resistance rates. We describe the clinical and molecular characteristics of four infections caused by KPC-3 K. pneumoniae strains.
碳青霉烯类抗生素(CARBs)是治疗产超广谱β-内酰胺酶(ESBL)肺炎克雷伯菌引起的感染的主要药物。丝氨酸碳青霉烯酶 KPC 的产生在美国令人震惊地增加,并且可能导致 CARB 耐药率上升。我们描述了由产 KPC-3 肺炎克雷伯菌引起的四种感染的临床和分子特征。