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成功使用高剂量替加环素和黏菌素联合治疗泛耐药肺炎克雷伯菌肺炎和菌血症。

Successful treatment of pan-resistant Klebsiella pneumoniae pneumonia and bacteraemia with a combination of high-dose tigecycline and colistin.

机构信息

UCLA David Geffen School of Medicine, Department of Pathology and Laboratory Medicine, Los Angeles, CA, USA.

Department of Medicine, Division of Infectious Diseases, David Geffen School of Medicine at UCLA, Los Angeles, CA, USA.

出版信息

J Med Microbiol. 2010 Nov;59(Pt 11):1383-1386. doi: 10.1099/jmm.0.023010-0. Epub 2010 Aug 5.

DOI:10.1099/jmm.0.023010-0
PMID:20688947
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC8482875/
Abstract

The spread of antimicrobial resistance among members of the Enterobacteriaceae is a significant clinical threat. We report the treatment of pan-resistant Klebsiella pneumoniae bacteraemia with combination tigecycline and colistin in a 49-year-old male and review available therapeutic options. Despite a poor prognosis, the patient recovered, but remains colonized with the pan-resistant isolate.

摘要

肠杆菌科成员中抗菌药物耐药性的传播是一个重大的临床威胁。我们报告了一例 49 岁男性泛耐药肺炎克雷伯菌菌血症患者使用替加环素联合黏菌素治疗的情况，并回顾了可用的治疗选择。尽管预后不佳，但患者康复，但仍定植有泛耐药分离株。

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