Institute for Health Science, Tokushima Bunri University, Nishihama, Tokushima-shi, 770-8514, Japan.
Anticancer Res. 2009 Nov;29(11):4861-5.
Recently, there has been interest in the tertiary functions of food, those that maintain human health. Moreover, lipopolysaccharides (LPS), which are components of Gram-negative bacteria, have been found to be highly effective in activating innate immunity and have been rediscovered as new functional food materials. In this review, we discuss the significance of LPS as a food component with reference to these tertiary functions based on recent findings. There is special emphasis on the plasticity of responses to LPS by intestinal macrophages. According to the macrophage-network theory, local macrophages cooperate with other tissue macrophages. For this reason, this review also discusses the possibility that information is transferred throughout the body from intestinal macrophages.
最近，人们对食物的第三功能（即维持人体健康的功能）产生了兴趣。此外，人们发现革兰氏阴性菌的组成成分脂多糖（LPS）在激活先天免疫方面非常有效，并被重新发现为新的功能性食品材料。在这篇综述中，我们根据最近的发现，讨论了 LPS 作为一种具有这些第三功能的食物成分的意义。特别强调了肠道巨噬细胞对 LPS 反应的可塑性。根据巨噬细胞网络理论，局部巨噬细胞与其他组织巨噬细胞合作。因此，这篇综述还讨论了信息从肠道巨噬细胞全身传递的可能性。
