Kaji T, Takata M, Miyahara T, Kozuka H, Koizumi F
Section of Toxicology, Faculty of Pharmaceutical Sciences, Toyama Medical and Pharmaceutical University, Japan.
Toxicol Lett. 1991 Mar;55(3):255-62. doi: 10.1016/0378-4274(91)90005-q.
To investigate the interaction between cadmium and copper in ossification, femurs from 9-day-old chick embryos were cultured for 6 days in the presence of 2 microM cadmium and/or 1 microM copper. It was found that cadmium + copper treatment caused interactively severe damage to osteogenic mesenchymal cells in the periosteum and a severe degenerative change in osteoblasts around the trabecula, resulting in severe impairment of ossification in the diaphysis. Cadmium content was increased by copper; however, copper content was unaffected by cadmium in the diaphysis. It was therefore considered that the copper-induced increase in cadmium content was a primary factor in the interactive toxic effect of the cadmium + copper treatment in ossification.
为研究镉与铜在骨化过程中的相互作用，将9日龄鸡胚的股骨在含有2微摩尔镉和/或1微摩尔铜的条件下培养6天。结果发现，镉+铜处理对骨膜中的成骨间充质细胞造成了相互作用的严重损伤，以及小梁周围成骨细胞的严重退行性变化，导致骨干骨化严重受损。骨干中的镉含量因铜而增加；然而，骨干中的铜含量不受镉的影响。因此，认为铜诱导的镉含量增加是镉+铜处理在骨化过程中产生相互作用毒性效应的主要因素。
