Department of Pharmacy, Faculty of Pharmacy, Mahidol University, Bangkok 10400, Thailand.
Molecules. 2009 Dec 1;14(12):4987-5000. doi: 10.3390/molecules14124987.
Aqueous extracts from seeds of Areca catechu L. (Arecaceae) (AC) and nutgalls of Quercus infectoria Oliv. (Fagaceae) (QI) were investigated for their hepatoprotective potential by studying their antioxidant capacity using four different methods, by determining their in vitro anti-inflammatory activity against 5-lipoxygenase, and by evaluating their hepatoprotective potential against liver injury induced by carbon tetrachloride (CCl(4)) in rats. AC and QI extracts exhibited potent antioxidant and anti-inflammatory activities. Treatment of rats with AC and QI extracts reversed oxidative damage in hepatic tissues induced by CCl(4). It is suggested that extracts rich in either condensed or hydrolysable tannins and known for their potent antioxidant and anti-inflammatory activities, may potentially confer protection against oxidative stress-induced liver injury. These data should contribute to evidence-based traditional medicines for anti-inflammatory and hepatoprotective effects of both extracts.
水提取物从种子 Areca catechu L. (Arecaceae) (AC) 和 Quercus infectoria Oliv. 的虫瘿(壳斗科) (QI) 进行了研究其肝保护潜力通过研究其抗氧化能力使用四种不同的方法，通过确定他们的体外抗炎活性对 5 -脂氧合酶，并通过评估其肝保护潜力对四氯化碳 (CCl(4)) 诱导的肝损伤在大鼠中。AC 和 QI 提取物表现出很强的抗氧化和抗炎活性。用 AC 和 QI 提取物治疗大鼠可逆转 CCl(4)诱导的肝组织氧化损伤。这表明，富含缩合或可水解单宁的提取物，具有很强的抗氧化和抗炎活性，可能对氧化应激诱导的肝损伤具有保护作用。这些数据将有助于基于证据的传统医学，用于抗炎和两种提取物的肝保护作用。
