荖叶提取物在抗炎和抗黑色素生成方面的作用。
The effects of areca catechu L extract on anti-inflammation and anti-melanogenesis.
机构信息
Department of Biochemistry, College of Natural Science, Chungbuk National University, Cheongju, Chungbuk, 361-763, South Korea.
出版信息
Int J Cosmet Sci. 1999 Aug;21(4):275-84. doi: 10.1046/j.1467-2494.1999.196590.x.
Ethanolic extract (CC-516) from Areca catechu L was prepared and its various biological activities were evaluated, CC-516 showed potent anti-oxidative, free radical scavenging, and anti-hyaluronidase activity. Anti-oxidative effect of CC-516 (IC _ 50: 45.4 mug/ml) was lower than butylated hydroxytoluene (IC _ 50: 5mug ml), but similar to tocopherol and higher than ascorbic acid. Especially, CC-516 exhibited relatively high free radical scavenging activity (IC _ 50: 10.2 mug/ml) compared to control. CC-516 inhibited effectively hyaluronidase activity (IC _ 50: 416 mug/ml), showed inhibition in vivo on delayed hypersensitivity as well as croton-oil induced ear edema in mice when it was topically applied. These results strongly suggest that CC-516 may reduce immunoregulatory/inflammatory skin trouble. Also, from the results, we have elucidated that CC-516 showed anti-allergic and anti-cytotoxicity activity. The whitening effect of CC-516 shown by the inhibition of mushroom tyrosinase activity with IC _ 50 of 0.48 mg/ml and of melanin synthesis in B16 melanoma cells. This study indicates that CC-516 is effective on anti-inflammatory/anti-melanogenesis, and can be used as a new agent for cosmetics.
从槟榔中提取的乙醇提取物（CC-516）已被制备，并对其各种生物活性进行了评估，CC-516 显示出强大的抗氧化、自由基清除和透明质酸酶抑制活性。CC-516 的抗氧化作用（IC _ 50：45.4 μg/ml）低于丁羟甲苯（IC _ 50：5μg/ml），但与生育酚相似，高于抗坏血酸。特别是，CC-516 表现出相对较高的自由基清除活性（IC _ 50：10.2 μg/ml），与对照相比。CC-516 能有效抑制透明质酸酶活性（IC _ 50：416 μg/ml），当局部应用时，能抑制体内迟发性过敏反应和小鼠巴豆油耳水肿。这些结果强烈表明，CC-516 可能减轻免疫调节/炎症性皮肤问题。此外，从结果中我们阐明了 CC-516 具有抗过敏和抗细胞毒性活性。CC-516 通过抑制蘑菇酪氨酸酶活性（IC _ 50 为 0.48mg/ml）和黑色素合成在 B16 黑色素瘤细胞中的作用显示出美白效果。这项研究表明，CC-516 对抗炎/抗黑色素生成有效，可作为化妆品的新制剂。
Zotero 插件