Yamamoto Y, Clower B R, Haining J L, Asari S, Smith R R
Department of Neurosurgery, University of Mississippi Medical Center, Jackson 39216.
Stroke. 1991 Mar;22(3):373-7. doi: 10.1161/01.str.22.3.373.
After dividing 21 cats into three equal groups, we exposed their right middle cerebral arteries transorbitally and adventitially irrigated them with 2 ml washed red blood cells, blood plasma, or saline. To determine arterial intimal platelet accumulation in each cat, we injected [111In]oxine-labeled platelets intravenously immediately before injecting the various experimental solutions. Animals were sacrificed 2 or 4 hours following the injection of labeled platelets. Irrigation with washed red blood cells produced a significantly greater intraluminal accumulation of platelets than irrigation with saline (p less than 0.05). Plasma tended to have less of an effect on platelet accumulation than washed red blood cells, but this difference was not significant. These data suggest that the adventitial blood fraction responsible for intimal platelet accumulation in cerebral arteries following subarachnoid hemorrhage may be derived mainly from the red blood cell fraction.
将21只猫分成三组后，经眶暴露其右侧大脑中动脉，并分别向动脉外膜注入2毫升洗涤红细胞、血浆或生理盐水。为了确定每只猫动脉内膜血小板的积聚情况，在注入各种实验溶液之前，立即静脉注射[111In]奥克辛标记的血小板。在注射标记血小板后2或4小时处死动物。与注入生理盐水相比，注入洗涤红细胞后管腔内血小板积聚显著增多（p小于0.05）。血浆对血小板积聚的影响往往小于洗涤红细胞，但这种差异不显著。这些数据表明，蛛网膜下腔出血后大脑动脉内膜血小板积聚的外膜血液成分可能主要来源于红细胞成分。
