Department of Radiology, Toho University Ohashi Medical Centre, Tokyo, Japan.
Eur Radiol. 2010 Jul;20(7):1631-5. doi: 10.1007/s00330-009-1698-6. Epub 2009 Dec 22.
The differences regarding adverse reactions in different low-osmolar non-ionic contrast media had not been investigated previously. Thus, the aims of this study were to identify differences in the incidence of adverse reactions in five different low-osmolar non-ionic contrast media.
We prospectively recorded all adverse events associated with five different low-osmolar non-ionic contrast media used in 8,931 consecutive patients for CT. Patients were randomly assigned to five groups: iomeprol 300 mgI/ml, iopamidol 300 mgI/ml, iohexol 300 mgI/ml, iopromide 300 mgI/ml and ioversol 320 mgI/ml.
Adverse events were observed in 241 patients (2.7%). The incidence of acute adverse reactions was significantly higher in the following groups: (1) iomeprol (3.9%) and iopromide (3.5%) groups, (2) patients aged 59 years or less (4.5%) compared with those aged 60 years or over (1.9%), (3) the first period (3.5%) compared with the late period (2.3%), (4) those with a past history of adverse reactions to contrast media (11.2%), and (5) patients receiving contrast media for the first time (3.3%) compared with those had received it previously (2.0%).
The incidence of acute adverse reactions may be reduced in younger patients by using iopamidol, iohexol and ioversol.
之前尚未研究过不同低渗非离子型对比剂的不良反应差异。因此，本研究旨在确定五种不同低渗非离子型对比剂不良反应发生率的差异。
我们前瞻性地记录了 8931 例连续 CT 检查中使用五种不同低渗非离子型对比剂的所有不良事件。患者被随机分配到五组：碘普罗胺 300mgI/ml、碘海醇 300mgI/ml、碘美普尔 300mgI/ml、碘帕醇 300mgI/ml 和碘佛醇 320mgI/ml。
241 例（2.7%）患者出现不良事件。急性不良反应发生率在以下组中显著更高：（1）碘美普尔（3.9%）和碘帕醇（3.5%）组，（2）59 岁及以下（4.5%）患者与 60 岁及以上（1.9%）患者相比，（3）第 1 期（3.5%）与晚期（2.3%）相比，（4）有对比剂不良反应史的患者（11.2%），（5）首次接受对比剂的患者（3.3%）与既往接受过对比剂的患者（2.0%）相比。
在年轻患者中使用碘海醇、碘美普尔和碘佛醇可能会降低急性不良反应的发生率。
