人白血病“裸”细胞系（NALL-1）

Human leukemic "null" cell line (NALL-1).

作者信息

Hiraki S, Miyoshi I, Kubonishi I, Matsuda Y, Nakayama T, Kishimoto H, Masuji H

出版信息

Cancer. 1977 Nov;40(5):2131-5. doi: 10.1002/1097-0142(197711)40:5<2131::aid-cncr2820400523>3.0.co;2-v.

DOI:10.1002/1097-0142(197711)40:5<2131::aid-cncr2820400523>3.0.co;2-v

Abstract

A human lymphoblast cell line, NALL-1, was established from the peripheral blood of a patient with acute lymphoblastic leukemia (ALL). NALL-1 cells had neither properties of T and B cells nor Epstein-Barr virus (EBV). Many characteristics of the NALL-1 line were distinct from those of numerous EBV-positive lymphoblastoid cell lines previously reported. NALL-1 cells are considered to have originated from the donor's leukemic cells on the basis of their cytogenetic, morphologic and functional features. The NALL-1 line is the first human leukemic "null" cell line derived from ALL. The significance of this cell line is disscussed.

摘要

一株人淋巴母细胞系NALL-1是从一名急性淋巴细胞白血病（ALL）患者的外周血中建立的。NALL-1细胞既不具备T细胞和B细胞的特性，也没有感染EB病毒（EBV）。NALL-1细胞系的许多特征与先前报道的众多EBV阳性淋巴母细胞系不同。基于其细胞遗传学、形态学和功能特征，NALL-1细胞被认为起源于供体的白血病细胞。NALL-1细胞系是首例源自ALL的人白血病“裸”细胞系。本文讨论了该细胞系的意义。

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