Hiraki S, Miyoshi I, Nakamura K, Ohta T, Watanabe Y, Tsubota T, Tanaka T, Kimura I
Gan. 1979 Dec;70(6):791-7.
Human leukemic B-cell (BALL-1), T-cell (TALL-1), and null-cell (NALL-1) lines were established from three patients with acute lymphoblastic leukemia (ALL). Intraperitoneal transplantation of these ALL cell lines into immunosuppressed newborn hamsters resulted in the development of invasive tumors in all recipients, except 4 of 10 implanted with NALL-1 line. BALL-1 and TALL-1 lines were serially transplanted for 10 and 9 passages, respectively. In addition to a common in vivo feature of mesenteric and retroperitoneal tumors, BALL-1 line was characterized by infiltration of the skin, massive ascites, and bone marrow invasion. TALL-1 cells infiltrated various organs including the lymph nodes, liver, bone marrow, central nervous system, eyes, etc. NALL-1 line grew slowly, producing the least number of tumors. Leukemic cells were detected in the blood of 24 of 25 hamsters bearing BALL-1 and in the blood of 18 of 24 hamsters bearing TALL-1. Thus, these three ALL cell lines were found to exhibit a characteristic biological behavior in hamsters.
从三名急性淋巴细胞白血病（ALL）患者体内建立了人白血病B细胞系（BALL-1）、T细胞系（TALL-1）和裸细胞系（NALL-1）。将这些ALL细胞系腹腔内移植到免疫抑制的新生仓鼠体内，除了10只植入NALL-1细胞系的仓鼠中有4只外，所有受体均发生侵袭性肿瘤。BALL-1和TALL-1细胞系分别连续传代10代和9代。除了肠系膜和腹膜后肿瘤这一共同的体内特征外，BALL-1细胞系的特点是皮肤浸润、大量腹水和骨髓浸润。TALL-1细胞浸润包括淋巴结、肝脏、骨髓、中枢神经系统、眼睛等在内的各种器官。NALL-1细胞系生长缓慢，产生的肿瘤数量最少。在携带BALL-1的25只仓鼠中的24只血液中以及携带TALL-1的24只仓鼠中的18只血液中检测到白血病细胞。因此，发现这三种ALL细胞系在仓鼠中表现出特征性的生物学行为。
