State Key Laboratory of Genetic Engineering, Institute of Genetics, School of Life Sciences, Fudan University, 200433 Shanghai, People's Republic of China.
Breast Cancer Res Treat. 2010 Jul;122(1):237-42. doi: 10.1007/s10549-009-0689-2. Epub 2009 Dec 24.
Breast cancer is the most common cancer in women. To date, many publications have evaluated the association between Cytochrome P450 1B1 (CYP1B1) Val432Leu polymorphism and breast cancer risk. However, the results remain inconclusive. In order to derive a more precise estimation of the association, a meta-analysis was performed in this study. By searching Medline, Pubmed, and ISI Web of Knowledge databases, 26 studies including 19,028 cases and 21,275 controls were collected for CYP1B1 Val432Leu polymorphism. Crude ORs with 95% CIs were used to assess the strength of association between CYP1B1 Val432Leu polymorphism and breast cancer risk. The pooled ORs were performed for codominant model, dominant model, and recessive model, respectively. Overall, no significant associations between CYP1B1 Val432Leu polymorphism and breast cancer susceptibility were found for Val/Val versus Leu/Leu (OR = 0.98; 95% CI: 0.90-1.06), Val/Leu versus Leu/Leu (OR = 1.01; 95% CI: 0.93-1.09), Val/Val + Val/Leu versus Leu/Leu (OR = 1.00; 95% CI: 0.93-1.08) and Val/Val versus Val/Leu + Leu/Leu (OR = 0.96; 95% CI: 0.91-1.01). In the stratified analysis by ethnicity, menopausal status and sources of controls, significant associations were still not observed in all genetic models. In conclusion, this meta-analysis provides strong evidence that CYP1B1 Val432Leu polymorphism is not associated with breast cancer risk.
乳腺癌是女性最常见的癌症。迄今为止，许多出版物都评估了细胞色素 P450 1B1（CYP1B1）Val432Leu 多态性与乳腺癌风险之间的关系。然而，结果仍不确定。为了更准确地评估这种关联，本研究进行了荟萃分析。通过搜索 Medline、Pubmed 和 ISI Web of Knowledge 数据库，共收集了 26 项研究，包括 19028 例病例和 21275 例对照，用于 CYP1B1 Val432Leu 多态性分析。使用粗比值比（OR）及其 95%置信区间（CI）来评估 CYP1B1 Val432Leu 多态性与乳腺癌风险之间的关联强度。分别采用共显性模型、显性模型和隐性模型进行汇总 OR 分析。总体而言，CYP1B1 Val432Leu 多态性与 Val/Val 与 Leu/Leu（OR=0.98；95%CI：0.90-1.06）、Val/Leu 与 Leu/Leu（OR=1.01；95%CI：0.93-1.09）、Val/Val+Val/Leu 与 Leu/Leu（OR=1.00；95%CI：0.93-1.08）和 Val/Val 与 Val/Leu+Leu/Leu（OR=0.96；95%CI：0.91-1.01）之间的相关性无显著差异。按种族、绝经状态和对照来源进行分层分析时，所有遗传模型均未观察到显著相关性。总之，本荟萃分析提供了强有力的证据表明，CYP1B1 Val432Leu 多态性与乳腺癌风险无关。
