调控秀丽隐杆线虫生殖力的精子与卵母细胞通讯机制。
Sperm and oocyte communication mechanisms controlling C. elegans fertility.
机构信息
Department of Cell Biology, University of Alabama at Birmingham, Birmingham, Alabama 35294, USA.
出版信息
Dev Dyn. 2010 May;239(5):1265-81. doi: 10.1002/dvdy.22202.
Abstract
During sexual reproduction in many species, sperm and oocyte secrete diffusible signaling molecules to help orchestrate the biological symphony of fertilization. In the Caenorhabditis elegans gonad, bidirectional signaling between sperm and oocyte is important for guiding sperm to the fertilization site and inducing oocyte maturation. The molecular mechanisms that regulate sperm guidance and oocyte maturation are being delineated. Unexpectedly, these mechanisms are providing insight into human diseases, such as amyotrophic lateral sclerosis, spinal muscular atrophy, and cancer. Here we review sperm and oocyte communication in C. elegans and discuss relationships to human disorders.
摘要
在许多物种的有性生殖过程中，精子和卵子会分泌扩散性信号分子，以帮助协调受精这一生物学交响乐。在秀丽隐杆线虫的性腺中，精子和卵子之间的双向信号对于指导精子到达受精部位和诱导卵子成熟非常重要。调节精子导向和卵子成熟的分子机制正在被描绘。出乎意料的是，这些机制为人类疾病（如肌萎缩侧索硬化症、脊髓性肌萎缩症和癌症）提供了新的见解。在这里，我们综述了秀丽隐杆线虫中精子和卵子的通讯，并讨论了与人类疾病的关系。
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