1 Department of Oral and Maxillofacial Biology, Graduate School of Oral Medicine, Matsumoto Dental University, Shiojiri, Japan.
2 Department of Oral Anatomy, Matsumoto Dental University, Shiojiri, Japan.
Mol Pain. 2018 Jan-Dec;14:1744806918804439. doi: 10.1177/1744806918804439. Epub 2018 Sep 13.
Transient receptor potential vanilloid 1 (TRPV1) is a nonselective cation channel that is expressed in the sensory neurons and responds to various noxious stimuli including heat and capsaicin. The molecular properties of TRPV1 have been clearly examined; however, there are obvious individual differences in human sensitivity to thermal stimuli and capsaicin. Here, we examined the possibility that different genome sequence of human TRPV1 caused the different sensitivity to heat or capsaicin. The sensitivities to burning pain and capsaicin of Japanese adult subjects were compared with their TRPV1 genome sequence, and we detected 6 single-nucleotide polymorphisms and 11 single-nucleotide polymorphisms related to burning pain and capsaicin sensitivity, respectively. In particular, homozygous I585V, a single-nucleotide polymorphism with amino acid substitution, significantly related to higher capsaicin sensitivity.
瞬时受体电位香草酸 1 型（TRPV1）是一种非选择性阳离子通道，在感觉神经元中表达，并对各种有害刺激（包括热和辣椒素）作出反应。TRPV1 的分子特性已被明确研究；然而，人类对热刺激和辣椒素的敏感性存在明显的个体差异。在这里，我们研究了人类 TRPV1 的不同基因组序列是否导致对热或辣椒素的敏感性不同。比较了日本成年受试者对灼痛和辣椒素的敏感性与其 TRPV1 基因组序列的关系，并分别检测到与灼痛和辣椒素敏感性相关的 6 个单核苷酸多态性和 11 个单核苷酸多态性。特别是，氨基酸取代的单核苷酸多态性 I585V 纯合子与更高的辣椒素敏感性显著相关。
