Fertility Centers of Illinois, Chicago, IL, USA.
Reprod Biomed Online. 2009;19 Suppl 4:4328.
Transfer of blastocyst-stage embryos has been shown to increase pregnancy rates while allowing for improved selection of potentially viable embryos. At this late stage of development, lower numbers of embryos can be transferred, resulting in less high-order multiple pregnancies and increased implantation rates. Between January 2004 and February 2009, 8449 blastocysts from 2453 patients were vitrified. After 1398 vitrified embryo transfers (VET) of both day-5 and day-6 blastocysts with a mean patient age of 34.6 +/- 5.0 years, the study centre has seen a survival rate of 96.3% (2730/2835), an implantation rate of 29.4% and a clinical pregnancy rate per VET of 42.8% (599 pregnancies/1398 warmed embryo transfers). After more than 5 years of vitrifying blastocysts, the perinatal outcome was, from 348 deliveries with vitrified blastocysts, the births of 431 babies (202 boys and 229 girls). One of the benefits of blastocyst vitrification is that it can be undertaken on a more flexible basis by laboratory staff. Also, vitrification may allow individual blastocysts to be cryopreserved at their optimal stage of development and expansion.
囊胚期胚胎移植已被证明可以提高妊娠率，同时允许更好地选择有潜在活力的胚胎。在胚胎发育的这个晚期阶段，可以减少胚胎的移植数量，从而减少多胎妊娠的高等级和提高着床率。2004 年 1 月至 2009 年 2 月，共有 2453 名患者的 8449 个囊胚被玻璃化。在进行了 1398 次含有第 5 天和第 6 天囊胚的玻璃化冷冻胚胎移植（VET）后，研究中心的存活率为 96.3%（2730/2835），着床率为 29.4%，每次 VET 的临床妊娠率为 42.8%（599 次妊娠/1398 次冷冻胚胎移植）。在进行囊胚玻璃化冷冻超过 5 年后，从 348 次囊胚玻璃化冷冻分娩中，共有 431 名婴儿（202 名男孩和 229 名女孩）出生。囊胚玻璃化的一个好处是，实验室工作人员可以在更灵活的基础上进行操作。此外，玻璃化可能允许在最佳的发育和扩张阶段单独冷冻保存囊胚。
