Joh Tong H, Park Hi-Joon, Kim Seung-Nam, Lee Hyejung
Department of Neurology and Neuroscience, Weill Cornell Medical College, New York, NY 10021, USA.
Neurol Res. 2010 Feb;32 Suppl 1:5-9. doi: 10.1179/016164109X12537002793643.
Parkinson's disease is a complex disease with multiple etiological factors involved in disease pathogenesis, and the molecular and cellular pathways for neurodegeneration are still elusive.
We reviewed all the relevant laboratory findings regarding acupuncture mechanism on Parkinson's disease.
Acupuncture treatments in animal experiments have generated valuable mechanistic insights of Parkinson's disease and shown that acupuncture therapy is in fact a neuroprotective therapy which increases various neuroprotective agents such as brain-derived neurotrophic factor, glial cell line-derived neurotrophic factor and cyclophilin A. In addition, acupuncture therapy decreases cell death processes and attenuates oxidative stress to substantia nigra dopaminergic neurons.
These results suggest that early application of acupuncture therapy for Parkinson's disease patients may be helpful for the best efficacy of acupuncture treatment.
帕金森病是一种复杂疾病，其发病机制涉及多种病因，神经退行性变的分子和细胞途径仍不明确。
我们回顾了所有关于针刺治疗帕金森病机制的相关实验室研究结果。
动物实验中的针刺治疗对帕金森病的机制产生了有价值的见解，并表明针刺疗法实际上是一种神经保护疗法，可增加多种神经保护因子，如脑源性神经营养因子、胶质细胞源性神经营养因子和亲环素A。此外，针刺疗法可减少细胞死亡过程，并减轻黑质多巴胺能神经元的氧化应激。
这些结果表明，早期对帕金森病患者应用针刺疗法可能有助于获得最佳的针刺治疗效果。
