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膜片钳:研究针灸机制的有力技术。

Patch clamp: a powerful technique for studying the mechanism of acupuncture.

机构信息

Department of Mechanics and Engineering Science, Fudan University, Shanghai 200433, China ; Shanghai Research Center for Acupuncture and Meridians, Shanghai 201203, China.

出版信息

Evid Based Complement Alternat Med. 2012;2012:534219. doi: 10.1155/2012/534219. Epub 2012 Oct 22.

DOI:10.1155/2012/534219
PMID:23133497
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC3485550/
Abstract

Cellular and molecular events can be investigated using electrophysiological techniques. In particular, the patch-clamp method provides detailed information. In addition, the patch-clamp technique has become a powerful method for investigating the mechanisms underlying the effects of acupuncture. In this paper, recent researches on how acupuncture might modulate electrophysiological responses in the central nervous system (CNS) and affect peripheral structures are reviewed.

摘要

细胞和分子事件可以用电生理学技术进行研究。特别是,膜片钳技术提供了详细的信息。此外,膜片钳技术已成为研究针刺作用机制的有力方法。本文综述了近年来关于针刺如何调节中枢神经系统(CNS)的电生理反应以及影响周围结构的研究。

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In vivo patch-clamp recording from locus coeruleus neurones in the rat brainstem.在体脑桥蓝斑神经元的膜片钳记录。
J Physiol. 2012 May 15;590(10):2225-31. doi: 10.1113/jphysiol.2011.226407. Epub 2012 Feb 27.
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Analgesic effect of electroacupuncture on chronic neuropathic pain mediated by P2X3 receptors in rat dorsal root ganglion neurons.电针对大鼠背根神经节神经元 P2X3 受体介导的慢性神经病理性疼痛的镇痛作用。
Neurochem Int. 2012 Mar;60(4):379-86. doi: 10.1016/j.neuint.2012.01.006. Epub 2012 Jan 18.
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Effect of electroacupuncture on serum copper, zinc, calcium and magnesium levels in the depression rats.电针对抑郁模型大鼠血清铜、锌、钙、镁水平的影响。
J Tradit Chin Med. 2011 Jun;31(2):112-4. doi: 10.1016/s0254-6272(11)60023-x.
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Mast-cell degranulation induced by physical stimuli involves the activation of transient-receptor-potential channel TRPV2.物理刺激引起的肥大细胞脱颗粒涉及瞬时受体电位通道 TRPV2 的激活。
Physiol Res. 2012;61(1):113-24. doi: 10.33549/physiolres.932053. Epub 2011 May 16.
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Acupuncture to point Baihui prevents ischemia-induced functional impairment of cortical GABAergic neurons.针刺百会穴预防脑缺血诱导的皮质 GABA 能神经元功能障碍。
J Neurol Sci. 2011 Aug 15;307(1-2):139-43. doi: 10.1016/j.jns.2011.04.021. Epub 2011 May 13.
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TRPV1 expression in acupuncture points: response to electroacupuncture stimulation.穴位中 TRPV1 的表达:对电针刺激的反应。
J Chem Neuroanat. 2011 Apr;41(3):129-36. doi: 10.1016/j.jchemneu.2011.01.001. Epub 2011 Jan 20.
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J Acupunct Meridian Stud. 2010 Dec;3(4):241-8. doi: 10.1016/S2005-2901(10)60043-X.
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