Lee Suh-Ha, Choi Hoyoung, Kim Hocheol, Lee Hyejung, Sung Yun-Hee, Kim Sung-Eun, Chang Hyun-Kyung, Shin Min-Chul, Shin Mal-Soon, Kim Chang-Ju
Department of Herbology, College of Korean Medicine, Kyung Hee University, Seoul 130-701, Korea.
Neurol Res. 2010 Feb;32 Suppl 1:58-63. doi: 10.1179/016164109X12537002794048.
Angelicae Tenuissimae Radix has traditionally been used for treating headache, flu-like symptoms, limb-ache and disability, and even for treating toothache. We investigated the anti-inflammatory and analgesic effect of Angelicae Tenuissimae Radix on lipopolysaccharide-induced inflammation.
For this study, 3-(4,5-dimethylthiazol-2-yl)-2,5-diphenyltetrazolium bromide assay, reverse transcription-polymerase chain reaction, prostaglandin E(2) immunoassay and nitric oxide detection in mouse BV2 microglial cells were performed.
Angelicae Tenuissimae Radix suppressed prostaglandin E(2) synthesis and nitric oxide production by inhibiting the lipopolysaccharide-induced expressions of cyclooxygenase-2 and inducible nitric oxide synthase messenger RNA in mouse BV2 microglial cells.
The present study indicates that Angelicae Tenuissimae Radix can be applied as a valuable treatment for brain inflammation and headache.
传统上，当归已被用于治疗头痛、流感样症状、肢体疼痛和功能障碍，甚至用于治疗牙痛。我们研究了当归对脂多糖诱导的炎症的抗炎和镇痛作用。
在本研究中，对小鼠BV2小胶质细胞进行了3-(4,5-二甲基噻唑-2-基)-2,5-二苯基四氮唑溴盐检测、逆转录-聚合酶链反应、前列腺素E(2)免疫检测和一氧化氮检测。
当归通过抑制脂多糖诱导的小鼠BV2小胶质细胞中环氧合酶-2和诱导型一氧化氮合酶信使核糖核酸的表达，抑制前列腺素E(2)的合成和一氧化氮的产生。
本研究表明，当归可作为治疗脑部炎症和头痛的有效药物。
