Cunningham D S, Fulgham D L, Rayl D L, Hansen K A, Alexander N J
Department of Obstetrics and Gynecology, United States Naval Hospital, Portsmouth, VA 23708.
Am J Obstet Gynecol. 1991 Mar;164(3):791-6. doi: 10.1016/0002-9378(91)90517-u.
Antisperm antibodies to sperm surface antigens in nulligravid women with primary upper genital tract infections were measured by the sperm mixed agglutination reaction assay. As many as 56% of women with a primary episode of pelvic inflammatory disease had antisperm antibodies. In addition, 69% of those women with no history of genital tract infection but with laparoscopic evidence of past pelvic infection had significant levels of circulating antisperm antibodies. Electroimmunoblots of sperm preparations probed with the sera of women who had either known or presumed upper genital tract infection revealed a uniformly recognized 69 kd antigen. In contrast, women with circulating antisperm antibodies before primary upper genital tract infection recognized up to five distinct sperm antigen determinants of 27, 54, 131, 146, and 174 kd. It is a distinct possibility that genital tract infections may lead to immunopotentiation of antisperm antibodies that could affect fertility.
通过精子混合凝集反应试验，对患有原发性上生殖道感染的未孕女性精子表面抗原的抗精子抗体进行了检测。多达56%的盆腔炎初发女性有抗精子抗体。此外，69%无生殖道感染史但腹腔镜检查有既往盆腔感染证据的女性，其循环抗精子抗体水平显著。用已知或推测有上生殖道感染的女性血清检测精子制剂的免疫印迹显示，有一种69kd抗原被一致识别。相比之下，原发性上生殖道感染前有循环抗精子抗体的女性，可识别多达5种不同的精子抗原决定簇，分别为27kd、54kd、131kd、146kd和174kd。生殖道感染很有可能导致抗精子抗体的免疫增强，进而影响生育能力。
