Witkin S S, Chaudhry A
Department of Obstetrics and Gynecology, Cornell University Medical College.
Am J Obstet Gynecol. 1989 Oct;161(4):900-3. doi: 10.1016/0002-9378(89)90747-3.
The relationship between antibodies on the surface of ejaculated sperm and circulating antibodies in female partners was evaluated. Of 616 couples examined by the immunobead binding test, there was a 12.4% incidence of sperm-surface antibodies in men whose wives had antisperm antibodies in their sera, but only a 6.5% incidence in partners of women who lacked these antibodies (p less than 0.025). Sperm-bound immunoglobulin G and immunoglobulin A both occurred at a significantly higher frequency (p less than 0.05) in partners of women with serum antisperm antibodies. Increased incidence of both immunoglobulin G (p less than 0.01) and immunoglobulin M (p less than 0.005) circulating antisperm antibodies in females were observed when the male partners had antibody-bound sperm. Antibody-coated sperm may activate lymphocytes in the female partners after coitus, thus leading to the production of antisperm antibodies. This may be an additional mechanism that leads to female isoimmunity to sperm and infertility.
对射出精子表面抗体与女性伴侣循环抗体之间的关系进行了评估。在通过免疫珠结合试验检测的616对夫妇中，妻子血清中有抗精子抗体的男性，其精子表面抗体的发生率为12.4%，而妻子缺乏这些抗体的男性伴侣中，精子表面抗体的发生率仅为6.5%（p<0.025）。在血清中有抗精子抗体的女性伴侣中，精子结合的免疫球蛋白G和免疫球蛋白A的发生率均显著更高（p<0.05）。当男性伴侣的精子有抗体结合时，女性循环抗精子抗体中免疫球蛋白G（p<0.01）和免疫球蛋白M（p<0.005）的发生率均增加。性交后，抗体包被的精子可能激活女性伴侣中的淋巴细胞，从而导致抗精子抗体的产生。这可能是导致女性对精子同种免疫和不孕的另一种机制。
