Laboratory of Reproductive Biology, Department of Developmental Biology, National Institute for Basic Biology, Okazaki, 444-8585, Japan,
Fish Physiol Biochem. 2005 Apr;31(2-3):105-9. doi: 10.1007/s10695-006-7590-2.
We have used various genetic and molecular approaches to investigate the mechanisms of sex determination and gonadal sex differentiation in fish. DMY was identified as the sex-determining gene of medaka. In tilapia, endogenous estrogens act as natural inducers of ovarian differentiation, while DMRT1 may be important for testicular differentiation. The roles of these regulators in sex determination and gonadal sex differentiation were ascertained using a gene or hormonal blockade strategy.
我们采用了各种遗传和分子方法来研究鱼类性别决定和性腺性别分化的机制。DMY 被鉴定为日本青鳉的性别决定基因。在罗非鱼中，内源性雌激素作为卵巢分化的天然诱导剂，而 DMRT1 可能对睾丸分化很重要。这些调节剂在性别决定和性腺性别分化中的作用是通过基因或激素阻断策略来确定的。
