Institut de recherches cliniques de Montréal, Bio-organic Chemistry Laboratory, 110 avenue des Pins Ouest, Montréal, Québec, Canada H2W 1R7.
Org Lett. 2010 Jan 1;12(1):36-9. doi: 10.1021/ol902414u.
An efficient synthesis of the C1-C17 western unit of narasin was achieved from (S)-Roche ester. Highlights in our synthesis include the successful exploitation of three stereoselective sequences of Lewis acid mediated reaction followed by free-radical-based hydrogen transfer.
从（S）-罗氏酯出发，高效合成了那拉菌素的 C1-C17 西体单元。我们的合成工作的重点包括成功利用了三种立体选择性的路易斯酸介导反应序列，然后是基于自由基的氢转移。
