亚膦介导的 1,4-噁嗪和 1,3-氧氮杂环戊烷的构建。
A phosphine-mediated construction of 1,4-oxazepines and 1,3-oxazines.
机构信息
CEA, iBiTecS, Service de Chimie Bioorganique et de Marquage, Gif sur Yvette, F-91191, France.
出版信息
Org Lett. 2010 Jan 1;12(1):40-2. doi: 10.1021/ol9024309.
PMID:20035563
Abstract
A simple and efficient method for constructing 1,4-oxazepines and 1,3-oxazines was developed with use of a phosphine-mediated tandem reaction of ynones with 2-azido alcohols. The method offers a promising route to synthetically useful as well as biologically active heterocycles under mild conditions and may be exploited for the preparation of interesting chiral ligands.
摘要
发展了一种简单高效的构建 1,4-恶嗪和 1,3-恶嗪的方法，该方法使用膦介导的炔酮与 2-叠氮醇的串联反应。该方法在温和条件下为合成有用的以及具有生物活性的杂环化合物提供了有前景的途径，并且可以用于制备有趣的手性配体。
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