Department of Psychology, Washington University in St. Louis, St. Louis, MO 63130, USA.
Neurobiol Aging. 2011 Dec;32(12):2162-71. doi: 10.1016/j.neurobiolaging.2009.12.009. Epub 2009 Dec 24.
Aging is characterized by a reduction in regional brain volumes, particularly in prefrontal and medial temporal regions. Recent evidence suggests that personality may be related to neuroanatomical integrity. The present investigation explored whether the three targeted personality traits of neuroticism, conscientiousness, and extraversion moderated cross-sectional age-related decline in measures of neural integrity. Estimates of the personality traits and volumes of cerebral gray and white matter, prefrontal and medial temporal regions were obtained in a sample of 79 healthy adults aged 44-88. Higher neuroticism was associated with smaller regional volumes and greater decreases in volume with increasing age. Higher conscientiousness was related to larger regional volumes and less decline with advancing age. These results suggest that personality may not only relate to, but may also moderate age-related cross-sectional decline in prefrontal and medial temporal regions.
衰老是区域性脑容量减少的特征，尤其是在前额叶和内侧颞叶区域。最近的证据表明，个性可能与神经解剖完整性有关。本研究探讨了神经质、尽责性和外向性这三个目标人格特质是否调节了神经完整性的横向年龄相关下降。在一个由 79 名年龄在 44-88 岁的健康成年人组成的样本中，获得了人格特质的估计值和大脑灰质和白质、前额叶和内侧颞叶区域的体积。较高的神经质与较小的区域体积和随年龄增长体积增加的较大减少有关。更高的尽责性与更大的区域体积和随年龄增长的较小减少有关。这些结果表明，个性不仅可能与前额叶和内侧颞叶区域的年龄相关的横断面下降有关，而且可能调节这种下降。
