Department of Bioscience and Biotechnology, Faculty of Agriculture, Kyushu University, Fukuoka, Japan.
FEBS Lett. 2010 Apr 2;584(7):1327-34. doi: 10.1016/j.febslet.2009.12.037. Epub 2009 Dec 27.
Autophagy is a non-selective degradation process in eukaryotic cells. The genome sequence of the fission yeast Schizosaccharomyces pombe has revealed that many of the genes required for autophagy are common between the fission yeast and budding yeast, suggesting that the basic machinery of autophagy is conserved between these species. Autophagy in fission yeast is specifically induced by nitrogen starvation based on monitoring a GFP-Atg8p marker. Upon nitrogen starvation, fission yeast cells exit the vegetative cell cycle and initiate sexual differentiation to produce spores. Most of the nitrogen used for de novo protein synthesis during sporulation derives from the autophagic protein degradation system. This review focuses on the recent advances in the role of autophagy in fission yeast.
自噬是真核细胞中的一种非选择性降解过程。裂殖酵母 Schizosaccharomyces pombe 的基因组序列揭示，许多自噬所需的基因在裂殖酵母和芽殖酵母之间是共有的，这表明自噬的基本机制在这些物种之间是保守的。裂殖酵母中的自噬是由氮饥饿特异性诱导的，通过监测 GFP-Atg8p 标记来实现。氮饥饿时，裂殖酵母细胞退出营养细胞周期，启动有性分化以产生孢子。孢子形成过程中用于从头合成蛋白质的大部分氮都来自于自噬蛋白降解系统。本文综述了自噬在裂殖酵母中的作用的最新进展。
