T-Life Research Center, Fudan University, Shanghai 200433, China.
J Biotechnol. 2010 Sep 1;149(3):115-9. doi: 10.1016/j.jbiotec.2009.12.015. Epub 2009 Dec 29.
Composition vector approach to prokaryotic phylogeny provides an alignment-free and parameter-free method based on whole-genome data. It has also been applied to viruses and fungi. In all studied cases the inferred phylogenetic relationships agree well with taxonomic knowledge in major groupings and fine branchings. In this review article, after demonstrating its successful application to a collection of 892 genomes including 62 Archaea, 822 Bacteria and 8 Eukarya, we will outline some ongoing work towards the foundations of this new approach.
基于全基因组数据的组成向量方法为原核生物系统发育提供了一种无需比对和无参数的方法。该方法也已应用于病毒和真菌。在所有研究案例中，推断出的系统发育关系与主要分类群和精细分支的分类学知识一致。在这篇综述文章中，在展示了其对包括 62 种古菌、822 种细菌和 8 种真核生物在内的 892 个基因组集合的成功应用之后，我们将概述为这一新方法奠定基础的一些正在进行的工作。
