在帕金森病患者中,手臂定位时的触觉/本体感觉整合完整。
Tactile/proprioceptive integration during arm localization is intact in individuals with Parkinson's disease.
机构信息
Neuroscience Department, New York College of Osteopathic Medicine, Northern Boulevard, Old Westbury, NY 11568, USA.
出版信息
Neurosci Lett. 2010 Feb 5;470(1):38-42. doi: 10.1016/j.neulet.2009.12.051. Epub 2009 Dec 30.
It has been theorized that sensorimotor processing deficits underlie Parkinson's disease (PD) motor impairments including movement under proprioceptive control. However, it is possible that these sensorimotor processing deficits exclude tactile/proprioception sensorimotor integration: prior studies show improved movement accuracy in PD with endpoint tactile feedback, and good control in tactile-driven precision-grip tasks. To determine whether tactile/proprioceptive integration in particular is affected by PD, nine subjects with PD (off-medication, UPDRS motor=19-42) performed an arm-matching task without visual feedback. In some trials one arm touched a static tactile cue that conflicted with dynamic proprioceptive feedback from biceps brachii muscle vibration. This sensory conflict paradigm has characterized tactile/proprioceptive integration in healthy subjects as specific to the context of tactile cue mobility assumptions and the intention to move the arm. We found that the individuals with PD had poorer arm-matching accuracy than age-matched control subjects. However, PD-group accuracy improved with tactile feedback. Furthermore, sensory conflict conditions were resolved in the same context-dependent fashion by both subject groups. We conclude that the somatosensory integration mechanism for prioritizing tactile and proprioception feedback in this task are not disrupted by PD, and are not related to the observed proprioceptive deficits.
人们推测,帕金森病(PD)运动障碍的运动感知处理缺陷包括本体感受控制下的运动。然而,这些运动感知处理缺陷可能不包括触觉/本体感受的运动感知整合:先前的研究表明,PD 患者在末端触觉反馈下运动准确性提高,在触觉驱动的精确抓握任务中控制良好。为了确定 PD 是否特别影响触觉/本体感受整合,9 名 PD 患者(停药,UPDRS 运动=19-42)在没有视觉反馈的情况下进行手臂匹配任务。在一些试验中,一只手臂触摸到一个与肱二头肌振动的动态本体感受反馈相冲突的静态触觉提示。这种感觉冲突范式将触觉/本体感受整合在健康受试者中描述为特定于触觉提示移动性假设和移动手臂的意图的背景。我们发现,PD 患者的手臂匹配准确性低于年龄匹配的对照组。然而,PD 组的准确性随着触觉反馈而提高。此外,两个受试者组都以相同的上下文相关方式解决了感觉冲突条件。我们得出结论,在这项任务中,用于优先考虑触觉和本体感受反馈的躯体感觉整合机制没有被 PD 破坏,并且与观察到的本体感受缺陷无关。