炎症与肿瘤发生：恶性循环。

Inflammation and oncogenesis: a vicious connection.

机构信息

Laboratory of Gene Regulation and Signal Transduction, Department of Pharmacology, School of Medicine, University of California, San Diego, 9500 Gilman Drive, La Jolla, CA 92093, USA.

出版信息

Curr Opin Genet Dev. 2010 Feb;20(1):65-71. doi: 10.1016/j.gde.2009.11.004. Epub 2009 Dec 25.

DOI:10.1016/j.gde.2009.11.004

PMID:20036794

原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC2821983/

Abstract

Epidemiological and experimental data suggest a close connection between inflammation and tumorigenesis. Solid tumors are typically infiltrated with immune cells and inflammation impacts most, if not all, stages of tumorigenesis. Molecular and cellular pathways, which connect inflammation and cancer, have emerged as attractive targets for prevention and therapy. In this review we discuss general mechanisms and concepts of cancer promoting inflammation.

摘要

流行病学和实验数据表明，炎症与肿瘤发生之间存在密切联系。实体瘤通常浸润有免疫细胞，炎症影响肿瘤发生的大多数（如果不是全部）阶段。将炎症与癌症联系起来的分子和细胞途径已成为预防和治疗的有吸引力的靶点。在这篇综述中，我们讨论了促进癌症炎症的一般机制和概念。