Universite Versailles St-Quentin, Centre National de la Recherche Scientifique, Ecole Pratiques des Hautes Etudes, UMR 8159, Laboratoire de Genetique et Biologie Cellulaire, 45 av. des Etats-Unis 78035 Versailles Cedex France.
Front Biosci (Landmark Ed). 2010 Jan 1;15(1):12-24. doi: 10.2741/3602.
The Hepatitis B virus (HBV) can induces severe liver diseases as chronic hepatitis and hepatocellular carcinoma. Actually, apoptosis can play an important role in the progress of these diseases. As apoptosis goes through various extrinsic or intrinsic pathways, with activation of caspases and the possible involvement of mitochondria, HBV proteins can interfere with the various apoptosis processes. So far, four HBV proteins were reported to have such effect: the Large envelope protein, a truncated form of the Middle envelope protein, the HBx protein and HBSP, a protein generated from a spliced mRNA. In addition, our recent results suggest that indirectly the precore protein could have a function in apoptosis. This review focuses on the putative roles of HBV proteins as pro- or anti-apoptotic factors and the relationship which could exist with the HBV life cycle.
乙型肝炎病毒 (HBV) 可引起慢性肝炎和肝细胞癌等严重肝脏疾病。实际上，细胞凋亡在这些疾病的进展中起着重要作用。由于细胞凋亡通过各种外在或内在途径进行，伴随着半胱天冬酶的激活和线粒体的可能参与，HBV 蛋白可以干扰各种凋亡过程。到目前为止，已有四种 HBV 蛋白被报道具有这种作用：大包膜蛋白、中包膜蛋白的截短形式、HBx 蛋白和 HBSP，这是一种从拼接 mRNA 产生的蛋白。此外，我们最近的研究结果表明，前核心蛋白可能具有凋亡的间接功能。这篇综述主要关注 HBV 蛋白作为促凋亡或抗凋亡因子的潜在作用，以及它们与 HBV 生命周期之间可能存在的关系。
