Bertino Enrico, Gastaldi Daniela, Monti Giovanna, Baro Cristina, Fortunato Donatella, Perono Garoffo Lorenza, Coscia Alessandra, Fabris Claudio, Mussap Michele, Conti Amedeo
Neonatal Unit, Department of Paediatric and Adolescence Science, University of Turin, Torino, Italy.
Front Biosci (Elite Ed). 2010 Jan 1;2(2):526-36. doi: 10.2741/e111.
Successful therapy in cow milk (CM) protein allergy rests upon completely eliminating CM proteins from the child's diet: it is thus necessary to provide a replacement food. Donkey milk (DM) has recently aroused scientific and clinical interest, above all among paediatric allergologists. A deeper knowledge of proteins in DM is necessary to evaluate the immunological and physiological properties of this natural substitute for cow's milk. The paper offers a detailed comparative analysis among the protein fractions of DM, CM and human milk, following an extensive proteomic study of the casein and whey proteins of DM performed by narrow pH range 2-DE. The detailed protein composition and structural features reported in this study provide insight into the molecular reasons for the hypoallergenicity of DM. Whole DM might constitute a valid substitute of CM in feeding children with CM protein allergy and it might also constitute the basis for formulas suitable for allergic subjects in the first year of life.
因此有必要提供替代食物。驴奶最近引起了科学界和临床界的兴趣，尤其是在儿科过敏症专家中。深入了解驴奶中的蛋白质对于评估这种牛奶天然替代品的免疫和生理特性至关重要。在对驴奶的酪蛋白和乳清蛋白进行了广泛的窄pH范围2-DE蛋白质组学研究之后，本文对驴奶、牛奶和人乳的蛋白质组分进行了详细的比较分析。本研究报告的详细蛋白质组成和结构特征为驴奶低过敏性的分子原因提供了见解。全驴奶可能是喂养牛奶蛋白过敏儿童时牛奶的有效替代品，也可能构成适合一岁以内过敏儿童的配方奶粉的基础。
