Ellison Georgina M, Galuppo Valentina, Vicinanza Carla, Aquila Iolanda, Waring Cheryl D, Leone Angelo, Indolfi Ciro, Torella Daniele
Stem Cell and Molecular Physiology Laboratory, The Research Institute for Sport and Exercise Sciences, Liverpool JM University, Liverpool, UK.
Front Biosci (Schol Ed). 2010 Jan 1;2(2):641-52. doi: 10.2741/s91.
For a long time the heart has been considered a terminally differentiated organ without any regenerative potential. The latter has been classically based on the terminally differentiated nature of cardiomyocytes and the absence of a pool of tissue-specific stem cells. This view has been radically changed due to the discovery of resident cardiac stem and progenitor cells in the adult mammalian heart. However, at minimum, 5 apparently different cardiac stem and/or progenitor cell types have been described so far. Thus, we have changed from a view of the heart as a static tissue to an organ with the highest number of tissue-specific stem cell populations. Most likely, the different putative adult cardiac stem and progenitor cells represent different developmental and/or physiological stages of a unique resident adult cardiac stem cell. Notably, it is not yet known the origin of all these cells. A better understanding of the origin, biology and physiology of the myocardial stem and progenitor cells will impact the development of regenerative medicine as an effective therapy for heart disease and failure.
长期以来，心脏一直被认为是一种终末分化器官，没有任何再生潜力。传统观点基于心肌细胞的终末分化特性以及缺乏组织特异性干细胞库。由于在成年哺乳动物心脏中发现了心脏驻留干细胞和祖细胞，这一观点发生了根本性改变。然而，到目前为止，至少已经描述了5种明显不同的心脏干细胞和/或祖细胞类型。因此，我们已经从将心脏视为静态组织的观点转变为认为心脏是具有最多组织特异性干细胞群体的器官。很可能，不同的假定成年心脏干细胞和祖细胞代表了独特的成年心脏驻留干细胞的不同发育和/或生理阶段。值得注意的是，目前尚不清楚所有这些细胞的起源。更好地了解心肌干细胞和祖细胞的起源、生物学和生理学将影响再生医学的发展，使其成为治疗心脏病和心力衰竭的有效疗法。
Zotero 插件