锌对成年雄性白化大鼠羟基氯喹诱导的心脏效应的保护作用。
Zinc's protective role against hydroxychloroquine-induced cardiac effects in adult male albino rats.
作者信息
Ibrahim Nihal A, Buabeid Manal A, Shaimaa Arafa El, Elmorshedy Kadreya E
机构信息
Department of Clinical Sciences, College of Pharmacy and Health Sciences, Ajman University, UAE.
Centre of Medical and Bio-allied Health Sciences Research (CMBAHSR), Ajman University, Ajman, UAE.
出版信息
Saudi J Biol Sci. 2023 Aug;30(8):103733. doi: 10.1016/j.sjbs.2023.103733. Epub 2023 Jul 4.
BACKGROUND
Long exposure to Hydroxychloroquine (HCQ) has been complicated by some dangerous though infrequent cardiotoxicity.
METHODS
A total of 40 normal adult male albino rats dispersed into 4 groups were used. Group 1 (Control group), Group II (HCQ treated group), Group III (zinc [Zn]-treated group), and Group IV (HCQ and Zn treated group). Once the experimentation ended, rats were sacrificed and cardiac soft tissue sections were processed twenty-four hours at the end of the experiment for histological study.
RESULTS
Cardiac-stained sections revealed that HCQ induced widespread necrosis, dilatation, and vacuolar degeneration. However, the combination of HCQ with Zn ameliorated these damaging effects. Cardiac enzyme parameters were also studied in the 4 groups and revealed CK-MB and troponin were considerably elevated in groups II associated to the control group.
CONCLUSION
It was concluded that Zn revealed a protective role against HCQ cardiomyopathy in adult male albino rats. This might signify an appreciated means for Zn-based treatment in the upcoming subsequent clinical records to adjust doses and guarantee patient safeguard.
背景
长期接触羟氯喹（HCQ）会引发一些危险但不常见的心脏毒性并发症。
方法
总共使用了40只成年雄性白化病正常大鼠，将其分为4组。第1组（对照组）、第2组（HCQ治疗组）、第3组（锌[Zn]治疗组）和第4组（HCQ和Zn治疗组）。实验结束后，处死大鼠，并在实验结束24小时后对心脏软组织切片进行处理，用于组织学研究。
结果
心脏染色切片显示，HCQ会引发广泛的坏死、扩张和空泡变性。然而，HCQ与Zn联合使用可改善这些损伤作用。还对4组大鼠的心脏酶参数进行了研究，结果显示，与对照组相比，第2组的肌酸激酶同工酶（CK-MB）和肌钙蛋白显著升高。
结论
得出的结论是，锌对成年雄性白化病大鼠的HCQ心肌病具有保护作用。这可能意味着在未来的临床记录中，基于锌的治疗是一种有价值的方法，可用于调整剂量并确保患者安全。
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