Iverson D A, Katsura H, Hartzer M K, Blumenkranz M S
William Beaumont Hospital, Royal Oak, Mich.
Arch Ophthalmol. 1991 Mar;109(3):405-9. doi: 10.1001/archopht.1991.01080030107048.
We studied the inhibition of intraocular fibrin formation following infusion of 5 IU/mL of low-molecular-weight heparin sodium (Fragmin, KabiVitrum AB, Stockholm, Sweden) during lensectomy, vitrectomy, and retinotomy in the rabbit model. Surgery was performed on 18 eyes, with nine receiving low-molecular-weight heparin and nine serving as controls. Masked postoperative examinations assessed fibrin quantity, corneal clarity, media clarity, and amount of vitreous hemorrhage. Five (56%) of nine eyes receiving low-molecular-weight heparin did not show fibrin exudation development, with the remainder demonstrating a minimal fibrin response. Eight (89%) of nine control eyes demonstrated prominent fibrin exudation, with five (56%) showing development of a fibrin clot that obscured two or more quadrants of the posterior chamber. No significant difference in the degree of vitreous hemorrhage was noted between groups. Corneal clarity was improved in the heparin-treated group.
我们在兔模型的晶状体切除术、玻璃体切除术和视网膜切开术中，研究了输注5 IU/mL低分子量肝素钠（速碧林，瑞典斯德哥尔摩卡比维特鲁姆公司）后对眼内纤维蛋白形成的抑制作用。对18只眼进行了手术，其中9只接受低分子量肝素治疗，9只作为对照。术后进行盲法检查，评估纤维蛋白量、角膜清晰度、介质清晰度和玻璃体出血量。接受低分子量肝素治疗的9只眼中，有5只（56%）未出现纤维蛋白渗出，其余显示出轻微的纤维蛋白反应。9只对照眼中有8只（89%）出现明显的纤维蛋白渗出，其中5只（56%）出现纤维蛋白凝块，遮挡了后房两个或更多象限。两组之间玻璃体出血程度无显著差异。肝素治疗组的角膜清晰度有所改善。
