Liu S M, Su Y T, Gupta P, Steidl S M
Department of Ophthalmology, University of Maryland School of Medicine, Baltimore, USA.
Retina. 1998;18(3):257-9. doi: 10.1097/00006982-199803000-00011.
To evaluate the efficacy of intraocular infusion of troxerutin in the inhibition of fibrin formation after vitrectomy in a rabbit model.
Lensectomies and vitrectomies were performed in a masked fashion on seven eyes treated with a 10-mM infusion of troxerutin and on seven control eyes that received only a balanced salt solution infusion. Masked grading of intraocular fibrin formation and intravitreal hemorrhage was performed for 1 week.
On postoperative days 1 and 2, the control group exhibited a greater mean fibrin index (MFI) percentage than the troxerutin-treated group (day 1, 27.7% versus 19.5% MFI; day 2, 14.5% versus 6.1% MFI, respectively). On postoperative day 3, both groups showed an MFI of 1.8%. On postoperative days 5 and 7, both groups showed only minimal presence of fibrin. Neither of the two groups had an increased rate of intraocular hemorrhage.
Infusion of 10 mM troxerutin resulted in a relative decrease in the amount of fibrin produced without an increased risk of intraocular hemorrhage in treated eyes compared with controls, but the difference was not statistically significant. Further studies may be warranted to evaluate the optimal dose of troxerutin alone or a possible role for its use in conjunction with other drugs employing a different mechanism of action in the prevention of fibrin formation.
在兔模型中评估玻璃体内输注曲克芦丁对玻璃体切除术后纤维蛋白形成的抑制效果。
对7只眼进行晶状体切除和玻璃体切除术，其中10只眼输注10 mM曲克芦丁，7只对照眼仅输注平衡盐溶液，手术采用盲法进行。对眼内纤维蛋白形成和玻璃体内出血进行1周的盲法分级。
术后第1天和第2天，对照组的平均纤维蛋白指数（MFI）百分比高于曲克芦丁治疗组（第1天，MFI分别为27.7%和19.5%；第2天，MFI分别为14.5%和6.1%）。术后第3天，两组的MFI均为1.8%。术后第5天和第7天，两组均仅显示极少量的纤维蛋白。两组的眼内出血率均未增加。
与对照组相比，输注10 mM曲克芦丁可使治疗眼产生的纤维蛋白量相对减少，且眼内出血风险未增加，但差异无统计学意义。可能需要进一步研究来评估单独使用曲克芦丁的最佳剂量，或其与其他具有不同作用机制的药物联合使用在预防纤维蛋白形成中的可能作用。
