Zhou Hua-bang, Xu Qin-rong, Wang Hui, Zhou Dong-xun, Wang Hao, Wang Qing, Zhou Shan-shan, Tu Qian-qian, Sun Zheng-qin, Ai Li, Wu Meng-chao, Hu He-ping
Department of Comprehensive Treatment II, Eastern Hepatobiliary Surgery Hospital, Second Military Medical University, Shanghai 200438, China.
Zhonghua Gan Zang Bing Za Zhi. 2009 Dec;17(12):935-9.
To explore the potential risk factors of intrahepatic cholangiocarcinoma (ICC) in China.
A case-control study including 317 patients with pathologically confirmed ICC and 634 healthy individuals was conducted. The cases and controls were matched in age, sex and inhabitancy. Data were statistically analyzed by Chi-square test and conditional logistic regression.
Univariate analysis showed significant difference in HBsAg seropositivity, liver cirrhosis, hepatolithiasis, choledocholithiasis and schistosomiasis between ICC patients and healthy controls (P < 0.05). Multivariate analysis confirmed that HBsAg seropositivity, liver cirrhosis, hepatolithiasis and hepatic schistosomiasis were associated with ICC, and their adjusted odds ratio (95% confidence interval) were 10.265 (6.676-15.783), 13.101 (5.265-32.604), 18.242 (3.580-92.958), 18.435 (1.930-176.082), 15.102 (4.607-49.499) and 11.820 (3.522-39.668), respectively. The incidence of hepatic cyst, cholecystolithiasis, hepatic hemangioma, fatty liver, diabetes mellitus, smoking and drinking were not significantly different between ICC patients and controls.
The HBV infection, liver cirrhosis, hepatolithiasis and hepatic schistosomiasis may be the risk factors for ICC in China.
探讨中国肝内胆管癌（ICC）的潜在危险因素。
进行一项病例对照研究，纳入317例经病理确诊的ICC患者和634名健康个体。病例和对照在年龄、性别和居住地区方面进行匹配。数据采用卡方检验和条件逻辑回归进行统计学分析。
单因素分析显示，ICC患者与健康对照在乙肝表面抗原（HBsAg）血清学阳性、肝硬化、肝内胆管结石、胆总管结石和血吸虫病方面存在显著差异（P<0.05）。多因素分析证实，HBsAg血清学阳性、肝硬化、肝内胆管结石和肝血吸虫病与ICC相关，其调整后的比值比（95%置信区间）分别为10.265（6.676 - 15.783）、13.101（5.265 - 32.604）、18.242（3.580 - 92.958）、18.435（1.930 - 176.082）、15.102（4.607 - 49.499）和11.820（3.522 - 39.668）。肝囊肿、胆囊结石、肝血管瘤、脂肪肝、糖尿病、吸烟和饮酒的发生率在ICC患者和对照之间无显著差异。
HBV感染、肝硬化、肝内胆管结石和肝血吸虫病可能是中国ICC的危险因素。
