Zou Sheng-quan, Liu Xiao-fang, Guo Ren-xuan, Li Chao-long, Zhou Xiao-si, Zhu Xue-guang, Huang Zhi-qiang
Department of General Surgery, Tongji Hospital Wuhan 430030, China.
Zhonghua Wai Ke Za Zhi. 2003 Jun;41(6):417-9.
In order to study the diagnosis and treatment of HBV and HCV infection.
We retrospectively analysed clinical data of 680 patients with cholangiocarcinoma from 1995 to 2001 and stated by SPSS software.
(1) The fastigium of cholangiocarcinoma was 60 - 65 years old. The incidence of cholangiocarcinoma was higher in aged males and the sex ratio (male:female) was 1.36:1. (2) The proximal cholangiocarcinoma was most (41.6%) and distant cholangiocarcinoma was secondly (28.7%). (3) Most patients of cholangiocarcinoma were late. The resection rate was low and the rate of radical operation was 21.6% (147/680). (4) The incidence of proximal cholangiocarcinoma was higher in the positive Serologic marks for HBV and HCV and course of diseases was short. Moreover, the pathology of. positive Serologic marks for HBV and HCV trended to low-differentiation and invasion, metastasis and the resection rate was lower.
Cholangiocarcinoma is common in the aged males. The infection of HB(C)V and hilar cholangiocarcinoma are correlated and incline to the proximal bile duct. The hilar cholangiocarcinoma infected HB(C)V may have higher malignant degree in biological characteristics and more badly prognosis.
研究HBV和HCV感染的诊断与治疗。
回顾性分析1995年至2001年680例胆管癌患者的临床资料，并用SPSS软件进行统计分析。
（1）胆管癌发病高峰年龄为60 - 65岁。老年男性胆管癌发病率较高，男女比例为1.36∶1。（2）近端胆管癌最多见（41.6%），远端胆管癌次之（28.7%）。（3）胆管癌患者大多就诊时已属晚期，切除率低，根治性手术率为21.6%（147/680）。（4）HBV和HCV血清学标志物阳性的近端胆管癌发病率较高，病程较短。而且，HBV和HCV血清学标志物阳性者病理上多倾向于低分化，易侵犯、转移，切除率较低。
胆管癌多见于老年男性。HB（C）V感染与肝门部胆管癌相关，且多倾向于近端胆管。感染HB（C）V的肝门部胆管癌可能具有较高的生物学恶性程度及较差的预后。
