Cho Sun-A, Han Ju-Hee, An Susun, Lee Key Hyun, Park Jae-Hak, Kim Han Kon, Lee Tae Ryong
Skin Research Institute, AmorePacific R&D Center, Yongin-si, Korea.
Cutan Ocul Toxicol. 2010 Mar;29(1):50-6. doi: 10.3109/15569520903471640.
In the present work, we assessed the relationship between alkyl carbon chain length and ocular irritation potentials using the hen's egg test-chorioallantoic membrane (HET-CAM) and bovine corneal opacity and permeability (BCOP) assays using 5 commercial alkyl polyglucoside surfactants with different compositions of alkyl chain lengths (C(6)-C(16)). With HET-CAM, there was a good correlation between the proportion of C(10) alkyl polyglucoside and the eye irritation potential Q score (r(2) = 0.912, p = .011). There were no significant differences between the proportion of C(10) alkyl polyglucoside and corneal opacity in BCOP assays; however, there was a relatively high positive correlation between the proportion of C(10) alkyl carbon chain lengths and corneal permeability (r(2) = 0.736, p = .063).
在本研究中，我们使用鸡胚绒毛尿囊膜试验（HET-CAM）和牛角膜混浊与通透性（BCOP）试验，评估了5种具有不同烷基链长度组成（C(6)-C(16)）的商用烷基多苷表面活性剂的烷基碳链长度与眼刺激潜力之间的关系。在HET-CAM试验中，C(10)烷基多苷的比例与眼刺激潜力Q评分之间存在良好的相关性（r(2)=0.912，p=0.011）。在BCOP试验中，C(10)烷基多苷的比例与角膜混浊之间没有显著差异；然而，C(10)烷基碳链长度的比例与角膜通透性之间存在相对较高的正相关性（r(2)=0.736，p=0.063）。
